Our paper on the effects of estradiol treatment on circadian rhythms in a rat model of menopause was published in Neurobiology of Aging! In this paper, we demonstrate that circadian rhythms in body temperature and activity can be boosted by exogenous estradiol treatment in aged rats, and this effect persists even when the treatment is delayed 3 months following ovariectomy (modeling menopause start). See the paper at this link.
Jeremy was awarded a NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation. This 2-year grant will supplement his work while starting his new lab at Cold Spring Harbor Laboratory. Specifically, this grant supports ongoing studies aiming to understand brain-periphery cross-talk and behavioral co-morbidities in cancer patients.
My K99/R00 Pathway to Independence grant to the National Cancer Institute was discussed on 6/27/19, and the following day was assigned an impact score of 10! Grants are scored on their potential impact from a score of 10 (best) to 90 (worst) in 1 point increments. This indicates that the grant will likely be funded. I am blown away by this score, and can’t wait to get started on the science! The grant is titled “Neuromodulation of subcortical circuits controlling cancer growth & metastasis”.
I had a great time speaking with a stellar group of researchers at the SBN annual meeting (see below). If you are interested in my work and want to join in, feel free to email me at firstname.lastname@example.org !
Our paper “Acute exposure to low-level light at night is sufficient to induce neurological changes and depressive-like behavior” has been published in Molecular Psychiatry. This work consists of a series of simple experiments demonstrating that short-duration (3 days) exposure to low levels of light at night can drastically alter depressive-like behavior and hippocampal gene expression. This is also the last paper I have from my graduate school lab ! A little fact about this paper…during the completion of this study we did behavioral testing every day for 2 months (including weekends etc…)!
William Walker II and myself have put up a new preprint of our paper “Molecular mechanisms of cancer-induced sleep disruption” to preprints.org . This is my first time publishing a pre-print….and I like it so far! In this review, we discuss emerging research that links the brain and cancer in the periphery. Specifically, we highlight how this cross-talk alters the host response to tumors, causing ‘collateral damage’ like sleep disruption, systemic inflammation, metabolic changes, and anorexia/cachexia.
After a long review process, a paper that we began working on over two years ago has been accepted for publication in Molecular Psychiatry. It is titled “Acute Exposure to Low Level Light at Night is Sufficient to Induce Neurological Changes and Depressive-like Behavior” with William Walker II as the lead author. The paper demonstrates that as little as 3 days of exposure to dim light at night induces larges changes in central gene expression and the development of depressive like behavior. Glad that this is seeing the light of day !