Paper published in Neurobiology of Aging!

Our paper on the effects of estradiol treatment on circadian rhythms in a rat model of menopause was published in Neurobiology of Aging! In this paper, we demonstrate that circadian rhythms in body temperature and activity can be boosted by exogenous estradiol treatment in aged rats, and this effect persists even when the treatment is delayed 3 months following ovariectomy (modeling menopause start). See the paper at this link.

Estradiol enhances biological rhythms in aged female rats.

Estradiol enhances biological rhythms in aged female rats.

K99/R00 Application receives best possible impact score!

My K99/R00 Pathway to Independence grant to the National Cancer Institute was discussed on 6/27/19, and the following day was assigned an impact score of 10! Grants are scored on their potential impact from a score of 10 (best) to 90 (worst) in 1 point increments. This indicates that the grant will likely be funded. I am blown away by this score, and can’t wait to get started on the science! The grant is titled “Neuromodulation of subcortical circuits controlling cancer growth & metastasis”.

Paper published in Molecular Psychiatry!

Our paper “Acute exposure to low-level light at night is sufficient to induce neurological changes and depressive-like behavior” has been published in Molecular Psychiatry. This work consists of a series of simple experiments demonstrating that short-duration (3 days) exposure to low levels of light at night can drastically alter depressive-like behavior and hippocampal gene expression. This is also the last paper I have from my graduate school lab ! A little fact about this paper…during the completion of this study we did behavioral testing every day for 2 months (including weekends etc…)!

Our paper demonstrates that low levels of light at night influence the expression of vascular endothelial growth factor (VEGF) and its receptors, along with cytokine mRNA, in the murine hippocampus. Pictured above is DyLight-594 labeled tomato lectin (red), which labels all active capillaries in the brain (Credit: JCB)

Our paper demonstrates that low levels of light at night influence the expression of vascular endothelial growth factor (VEGF) and its receptors, along with cytokine mRNA, in the murine hippocampus. Pictured above is DyLight-594 labeled tomato lectin (red), which labels all active capillaries in the brain (Credit: JCB)

New review paper available online as a preprint

William Walker II and myself have put up a new preprint of our paper “Molecular mechanisms of cancer-induced sleep disruption” to preprints.org . This is my first time publishing a pre-print….and I like it so far! In this review, we discuss emerging research that links the brain and cancer in the periphery. Specifically, we highlight how this cross-talk alters the host response to tumors, causing ‘collateral damage’ like sleep disruption, systemic inflammation, metabolic changes, and anorexia/cachexia.

figureone.jpg

Paper accepted in Molecular Psychiatry !

After a long review process, a paper that we began working on over two years ago has been accepted for publication in Molecular Psychiatry. It is titled “Acute Exposure to Low Level Light at Night is Sufficient to Induce Neurological Changes and Depressive-like Behavior” with William Walker II as the lead author. The paper demonstrates that as little as 3 days of exposure to dim light at night induces larges changes in central gene expression and the development of depressive like behavior. Glad that this is seeing the light of day !

Acute changes in locomotor behavior in response to light at night.

Acute changes in locomotor behavior in response to light at night.